Rasburicase-induced fatal respiratory arrest?
نویسندگان
چکیده
Urate oxidase is an endogenous enzyme found in most mammals but not in humans. Urate oxidase catalyzes the enzymatic oxidation of uric acid into allantoin, a metabolite that is 5–10 times more soluble in urine than uric acid. With complementary DNA technology it is possible to produce large quantities of the pure recombinant protein [1]. Rasburicase (RS), a recombinant form of urate oxidase, has been demonstrated to be superior to allopurinol in the control of uric acid production associated with acute leukemias and high-grade lymphomas (2).
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ورودعنوان ژورنال:
- Annals of oncology : official journal of the European Society for Medical Oncology
دوره 18 2 شماره
صفحات -
تاریخ انتشار 2007